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WEDNESDAY, May 13, 2015 (HealthDay News) -- The deadly Ebola virus has continued to mutate during the West African epidemic, but at the same rate as previous outbreaks, a team of genetic researchers has found.

Genetic analysis of samples taken from 175 Ebola patients in Sierra Leone found the genetic diversity of the virus has increased substantially, the researchers report May 13 in the journal Nature.

Their research reveals a "family tree" of Ebola strains that has emerged as the virus passed from person to person, including seven new lineages that evolved from the original strain that started the epidemic, the study says.

However, the Chinese researchers agree with other recent studies that have concluded Ebola is mutating (changing genetically) at its normal rate.

"Ebola, like all viruses, mutates as it infects individuals," said Dr. Amesh Adalja, a senior associate at the Center for Health Security at the University of Pittsburgh Medical Center. "This study provides evidence that, not surprisingly, during the West African outbreak the virus has mutated at a rate similar to past outbreaks and has formed new lineages."

A study published in March in Science found Ebola samples taken in Guinea also mutating at the same rate as previously observed.

Some public health experts had worried that the current Ebola epidemic -- the worst in history -- would promote increased evolution of the virus, giving it the chance to grow more virulent forms. For instance, some feared the virus, now transmitted through direct contact with infected blood or bodily fluids, would mutate into a form that could spread in the air.

While news from this study provides reassurance that Ebola will not go airborne anytime soon, such new genetic information is also critical in planning for future outbreaks as well as dealing with the ongoing West African epidemic, said Ebola expert Dr. Lee Norman, chief medical officer for the University of Kansas Hospital.

The current epidemic has centered around the nations of Liberia, Guinea and Sierra Leone. More than 11,000 people have died, and as many as 26,700 may have been infected with Ebola, according to the U.S. Centers for Disease Control and Prevention.

"It's not a moot question, where did it come from and where will it go, because that's important for us to understand so we can stay one step ahead of it," Norman said. "Forecasting of disease is imprecise at best, but if you take all that family tree information and map it out over time, it tells us where we should go to head it off at the pass."

New genetic information also provides clues whether vaccines and medications now being developed for Ebola will be effective against future strains of the virus, Adalja said.

"It will be important to understand how these new lineages fare against developing vaccines and antivirals," he said.

However, Adalja emphasized that Ebola's ongoing mutation during the epidemic "is not something that is unprecedented or unexpected, nor able to confer wholly new attributes on the virus."

The World Health Organization declared the end of the Ebola outbreak in Liberia on Saturday, after no new cases of Ebola surfaced over 21 days. That's the virus' maximum incubation period.

Norman said he hopes public health officials in Liberia will remain on guard, given that disease reporting can be sketchy in impoverished countries.

"We wouldn't want to reduce our efforts until we have pretty darned good evidence" that the epidemic is truly over, he said.

Copyright © 2015 HealthDay. All rights reserved.SOURCES: Amesh Adalja, M.D., FACP, FACEP, senior associate, Center for Health Security, University of Pittsburgh Medical Center, Baltimore, Md.; Lee Norman, M.D., chief medical officer, University of Kansas Hospital, Kansas City, Kan.; May 13, 2015, Nature

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Anecdotal reports of nursing mothers have long suggested that giving milk is a lot easier in second and subsequent pregnancies, compared with a first pregnancy. Now, researchers at Cold Spring Harbor Laboratory (CSHL) are able to explain why.

Their work shows the mammary gland forms a long-term memory of pregnancy that primes it to respond to the hormonal changes that announce succeeding pregnancies. The memory lasts throughout an individual's reproductive years. The results appear online in Cell Reports.

Secretion of the hormones estrogen and progesterone set the stage for dramatic changes that take place in the breast during pregnancy: a massive proliferation of mammary epithelial cells, and the formation of thousands of ductal structures, which support milk production and transport during lactation.

A team led by HHMI Investigator Greg Hannon, a CSHL Professor and also a Professor and Senior Group Leader at the CRUK Cambridge Institute at the University of Cambridge, hypothesized that pregnancy might alter the gland's receptiveness to pregnancy-related hormones. Specifically, they sought to determine if this might occur via changes in a set of chemical marks that attach to DNA, the genetic material. Such marks - molecules of methyl (CH3), for instance -- are called epigenetic marks, and their presence or absence in particular locations in the genome can either prevent genes from being expressed, or promote their expression.

Camila dos Santos, now a CSHL Assistant Professor, developed a technique critical to the newly reported experiments when she was a postdoctoral investigator in the Hannon lab. Dos Santos found a marker of mammary stem cells that enabled her to isolate highly purified stem cells in addition to a number of other cell types specific to the mouse mammary gland - six in all. From these, she generated genome-wide profiles of where methyl groups attach to the DNA. Of all the epigenetic marks, methyl marks tend to be the longest lasting, and are often permanent.

Working with Andrew Smith, a computational biologist from the University of Southern California, they found that cells sampled from young mice that had been through a single pregnancy cycle had methylation marks that were "substantially different" from marks in cells sampled from mice of the same age that had never been pregnant. "Of those changes," says Hannon, "we were able to trace a majority to places in the genome where a single transcription factor, called Stat5a, binds. This is really remarkable - so many changes in methylation, and you can track them down to a single factor." Like all transcription factors, Stat5a binds to DNA and in so doing changes the way a specific gene or genes are expressed.

The team shows that a first pregnancy erases many methyl marks that are present throughout life leading up to pregnancy. During a first pregnancy, the team suggests, Stat5a binds DNA in certain types of mammary epithelial cells, at places near genes that need to be activated during pregnancy - specifically, genes involved in proliferation and lactation. As the team showed in mice, when a once-pregnant female receives hormones whose action simulates a real pregnancy, the mice respond more rapidly than other, never-pregnant mice given the same hormones. In the previously pregnant mice, "the mammary glands start expanding faster and also sooner than for those experiencing pregnancy hormones for the first time," says dos Santos. "It's as if the gland already knows those hormones."

"This is an example of epigenetic memory: it is the loss of DNA methylation that is now marking sites in the genome that were active in a previous pregnancy," dos Santos says. When the same sites were examined a year after pregnancy (or exposure to pregnancy hormones), they remained unoccupied by methyl marks. "The cell is not replenishing DNA methylation at these sites, even after several cell divisions, which means the memory of previous pregnancy is long-term."

These findings have led to another important line of research. It is well known that women who become pregnant by age 25 have substantially lower rates of breast cancer than women who bear children later in life or not at all. It is possible that the implied protective factor is in some way related to the epigenetic memory of mammary cells just discovered, Hannon says.

Dos Santos says her lab is now "trying to understand which of the modifications we found in this study might prevent development of breast cancer in a pregnancy-related manner."

These images show the effect of pregnancy hormones after 6 and 12 days on breast tissue in mice that have never been pregnant (top row) and mice that have been pregnant once before (bottom row). The mammary gland in previously pregnant mice responds earlier and produces more branching ductal structures, used in lactation. New research shows breast tissue retains a cellular memory of prior pregnancy that makes response more rapid and vigorous in subsequent pregnancies.
Credit: Hannon lab, CSHL