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MedicationsSupplements and Vitamins home > heart center > heart a-z list > cholesterol drugs may lower stroke risk in healthy article

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TUESDAY, May 19, 2015 (HealthDay News) -- Healthy older adults who take cholesterol-lowering drugs may be cutting their risk of stroke, a new French study suggests.

The study found that when people took medications called statins or fibrates, their risk of stroke over almost a decade went down by about one-third.

But, lead researcher Dr. Christophe Tzourio, a professor of epidemiology at the University of Bordeaux and Inserm in France, doesn't think older people should start taking these drugs solely for stroke prevention.

"Our results should not be interpreted as an indication for prescribing statins or fibrates to elderly individuals. We wouldn't recommend changing medications based on the results of only one study," he said.

"The next step is to see whether we can replicate our findings or not," he added.

The report was published May 19 in the BMJ.

Statins include drugs such as Lipitor and Zocor. Fibrates, such as Bezalip and Tricor, are prescribed to patients who can't take statins or who need additional help getting their cholesterol levels down.

Dr. Gregg Fonarow, a professor of cardiology at the University of California, Los Angeles, said, "Randomized clinical trials have demonstrated that statins substantially lower the risk of heart attack and stroke, as well as overall death in men and women, with benefits that outweigh the risk."

Statins together with a healthy lifestyle are recommended in guidelines for adults at increased risk for heart attack and stroke, even when cholesterol levels are normal, he said. "Statin therapy along with maintaining a healthy blood pressure are two of the most efficacious and cost effective ways to prevent strokes," Fonarow said.

Although some experts have questioned the use of statins in adults older than 75, most studies show that statins provide benefits that outweigh the risks, regardless of a patient's age, he said.

Fonarow said that although statins have been associated with a lower risk for stroke, no such evidence has been seen for fibrates.

"Although this study also suggests there was a benefit with fibrates, most clinical trials have failed to find a meaningful benefit with fibrate therapy," he said.

For the current study, Tzourio's team collected data on nearly 7,500 French men and women, average age 74 years, with no history of heart attack or stroke when the study began.

During an average follow-up of nine years, the investigators found that those who took statins or fibrates had a one-third lower risk of stroke compared with those who didn't take them. No association, however, was found between statins and a lower risk of heart disease in this group, the researchers said.

The reduction in the risk of stroke attributed to statins did not change when the researchers took into account other factors such as age, sex, weight, blood pressure and cholesterol levels. However, because this was an observational study, the findings do not prove a cause-and-effect relationship.

"If confirmed, these results suggest that keeping patients on cholesterol-lowering drugs could lower their stroke risk," Tzourio said. "But these findings should not be interpreted as an indication for starting these drugs in older adults," he added.

MedicalNews
Copyright © 2015 HealthDay. All rights reserved.SOURCES: Christophe Tzourio, M.D., Ph.D., professor, epidemiology, University of Bordeaux and Inserm, France; Gregg Fonarow, M.D., professor, cardiology, University of California, Los Angeles; May 19, 2015, BMJ

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MedicationsSupplements and Vitamins home > heart center > heart a-z list > early menopause lowers irregular heartbeat risk article

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FRIDAY, May 15, 2015 (HealthDay News) -- Women who go through menopause at a relatively young age may have a slightly lower risk of developing a common heart rhythm disturbance, new research suggests.

The study, of nearly 18,000 middle-aged and older U.S. women, found that those who'd gone through menopause before age 44 were 17 percent less likely to have atrial fibrillation.

Atrial fibrillation is a common disorder where the heart's upper chambers quiver chaotically instead of contracting in a normal rhythm. It's not immediately life-threatening, but over time the condition can raise the risk of a stroke or heart failure.

The fact that earlier menopause was linked to a lower risk of the irregular heartbeat was "a bit surprising," said lead researcher Dr. Jorge Wong, a fellow at Brigham and Women's Hospital in Boston.

That's because early menopause is actually connected to a heightened risk of heart disease -- where plaques build up in the arteries and sometimes lead to a heart attack.

Since estrogen production drops after menopause, experts believe the hormone has a protective effect against heart disease, Wong said.

So why would earlier menopause potentially lower the risk of atrial fibrillation?

It's not clear, according to Wong. But he said that, in general, the risk factors for heart disease and atrial fibrillation are complex -- and "sometimes divergent."

"We suspect the lower [atrial fibrillation] risk could be related to a woman's total duration of estrogen exposure," Wong said. "What's really interesting is, this could give us clues to the mechanisms underlying [the irregular heart rhythm disorder]."

Wong was scheduled to present the findings Friday at the Heart Rhythm Society annual meeting, in Boston. Studies reported at meetings are usually considered preliminary until they are published in a peer-reviewed journal.

Because of that, the finding should be viewed cautiously, said Dr. Anne Gillis, past president of the Heart Rhythm Society and a professor of medicine at the University of Calgary, in Canada.

"The results are interesting, but it's hard to interpret what the implications could be," Gillis said.

For one, she pointed out, the study shows only an association between menopause timing and atrial fibrillation -- and doesn't prove cause-and-effect.

"Why did these women go through menopause at a younger age?" Gillis said. "Maybe there are additional factors that we don't understand yet."

Wong said his team accounted for the factors they could -- including whether the women were overweight, had high blood pressure or diabetes, or used hormone therapy after menopause.

And there was still a connection between menopause timing and the irregular heartbeat. However, Wong agreed that more research is needed to verify that the link is real -- and then to figure out why it exists.

Women cannot control the timing of menopause, of course. But if age at menopause is a factor in the development of atrial fibrillation, that might help doctors zero in on patients who are at relatively greater risk, according to Wong.

Gillis agreed. But for now, she recommended that women focus on known risk factors that can be changed -- such as uncontrolled high blood pressure and diabetes. She also said women should tell their doctor about any heart palpitations, since that can be a symptom of atrial fibrillation.

Over 2.5 million Americans have the heart rhythm disorder, according to the Heart Rhythm Society. Besides palpitations, symptoms include chronic fatigue, shortness of breath, and dizziness or lightheadedness.

Treatment often involves drugs that control the heart's rhythm and rate, and blood thinners to prevent blood clots and stroke.

MedicalNews
Copyright © 2015 HealthDay. All rights reserved.SOURCES: Jorge Wong, M.D., postdoctoral fellow, Brigham and Women's Hospital, Boston; Anne Gillis, M.D., professor, medicine, University of Calgary, Alberta, Canada; May 15, 2015, presentation, Heart Rhythm Society annual meeting, Boston

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